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HT/GMP inverting filter centrifuge

Inverting filter centrifuge HT/GMP with high separation efficiency is designed for typical pharmaceutical applications with slow filtering and compressible cakes (API and HPAPI).

HT/GMP centrifuge is used for the production of chemicals and mainly pharmaceuticals synthesis, products where it is absolutely necessary to avoid the contact between product and operator.

This type of centrifuges is a perfect choice when it comes to gentle handling of the crystals. Solids discharge is achieved by means of the filter cloth inversion, and soft crystals are recovered without breakage

Centrifugation phase can be enhanced by using nitrogen at 6 barg inside the basket (Hyperbaric Centrifugation System) to reduce the residual moisture (centrifuge dryer). Slight internal inerting pressure also helps to avoid undesirable ingress of oxygen and prevents the leakage of substances from the centrifuge.

Pilot model

HT/GMP pilot centrifuge may be used for many applications:

- Research and development

- Small productions or working with high added value products

- Scale-up

HT/GMP pilot centrifuges have the following features:

- They are skid-mounted

- Operated manually of automatically

- cGMP design

- Fully inspectable process area

HT/GMP inverting filter centrifuge by Comi Condor on manufacturer’s site

HT/GMP inverting filter centrifuge pilot model by Comi Condor on manufacturer’s site.

MediBalt Ltd - representative of Comi Condor

Priedaines Str. 13-1, LV-1029 Riga, Latvia

Phone Riga: +371 67373144, Fax: +371 67373143

Phone Moscow: +7 (499) 703-04-06

E-Mail: info@medibalt.com

www.medibalt.info

Model description

- Absolutely no contact between product and operator

- Even cake distribution due to the horizontal design

- Due to the short discharging time and the complete elimination of the heel cake at every cycle, it’s possible to work with thin cakes allowing to separate products with low filtering properties (fine particles, high compressibility), achieving a very good/uniform cake washing;

- COMI CONDOR has developed a completely openable casing that allows the inspection of the rear wall of the basket and avoid dead zones in the process area.

- Capability of pre-drying or even drying (for some products) thanks to the HCS (Hyperbaric Centrifugation System), supplying N2 at max 6 barg into the basket for further dewatering the capillaries inside the cake (reduction of the residual moisture)

- C.I.P.: very good possibility of achieving an efficient C.I.P. (Clean In Place) thanks to the use of the W.M.E. (Washing Machine Effect) and spray balls.

- Easy installation (isolation from unbalance loads by means of rubber dumpers);

- Through the wall installation;

- No contact between operator and product during operation;

- Electromechanical filter cloth inversion (oil free execution);

- Various levels of containment at solids discharge

- Complete FDA validation documentation

	PRODUCTION Feeding The solid-liquid suspension is fed through the feed pipe into the centrifuge and under the action of centrifugal force it moves towards the filter cloth, placed on a perforated basket. The solid part of the suspension is retained by the filter cloth forming a cake, while the liquid filters through the cake and the cloth and is discharged through the holes of the basket. The feed pipe is located at the center of the basket. A loading cell measures the product weight fed to the basket and stops the feeding when the desired weight is reached.
	Cake washing The washing liquid is fed through the feed pipe. The basket internal geometry and the feed pipe position cause a turbolence in the washing liquid and its uniform distribution in the cake.
	Final deliquoring (Centrifugation) Once completed the washing phase, the centrifuge is accelerated to the maximum speed and maintained for a given time to achieve the desired level of product residual humidity in the product.
	Further deliquoring (with Hyperbaric Centrifugation System – HCS) If the centrifugal force cannot further deliquor the capillaries inside the cake (poor filtration products), Hyperbaric Centrifugation System (HCS) can reduce residual moisture blowing nitrogen at high pressure (till 6 bar) into the basket. The nitrogen pressure and its flow reduce further the capillary height and the liquid around the product crystals, decreasing the residual moisture. If the nitrogen is also heated up, an additional evaporation effect is achieved.
	Solid discharge At the end of the centrifugation, the centrifuge reaches the discharging speed and the product is discharged. The mobile part of the basket is moved to the front part of the machine by means of the axial movement of the inverting shaft. This movement generates the inversion of the filter cloth and the discharge of the product.
	CLEAN IN PLACE (C.I.P.) Washing Machine Effect (WME) The centrifuge is filled with the washing liquid up to a predetermined height and put in rotation. During the sequence, the basket rotates clockwise and counterclockwise. the mobile drum goes in and out so that the washing liquid reaches all the points of the process area.
	Cleaning with spray balls The cleaning liquid is sprayed through all the spray balls on all the process area surfaces to completely remove the residues of product still present.

Centrifuge Model: HT/GMP	Basket diameter	Basket length	Filtering surface	Cake volume	Slurry density	Max load	Max speed	G factor	Centrifuge weight
Unit	mm	mm	m²	dm³	kg/dm³	kg	RPM	xg	kg
300/110	300	110	0,1	7	1,25	9	3150	1663	1400
470/180	470	180	0,27	27	1,25	34	2300	1390	3000
600/225	600	225	0,45	52	1,25	65	2000	1340	4000
700/225	700	225	0,52	65	1,25	81	1850	1338	4600
800/350	800	350	0,90	122	1,25	152	1600	1144	8500
900/350	900	350	1	145	1,25	181	1500	1131	8700
1000/430	1000	430	1,35	210	1,25	262	1350	1018	9400

Drive: Electric motor drive with frequency converter for the rotor and for the filter cloth inverting system.

Filter cloths available of PP of Halar or PTFE.

Gas tightness: in accordance with DIN 24400, 400 mm H2O.

No cross-contamination due to the CIP washing system. To completely clean the process zone by creating water fluctuations, it is also possible to partially flood the process area (washing machine effect). Automatic washing cycle consists of a sequence of alternating washes applying these two methods.

Inversion: Electromechanical system for inverting filter cloth, suitable for hazardous areas.

Suspension: with elastic dampers, damping possible dynamic loads and minimizing transmitted loads. So a centrifuge can be installed on a simple frame, avoiding the use of heavy concrete foundations.

Surface polishing: Multiple levels of polishing - up to mirror and / or electrochemical polishing.

- Materials in contact with the product: all stainless steels and special alloys available, such as AISI 316L, AISI 904L, Hastelloy, Monel, ALLOY 59, 254 SMO, NICKEL, TITANIUM, SAF 2205. HALAR coatings (ECTFE), also antistatic and FDA certificated, Teflon ETFE, HARD RUBBER.

Centrifuge Model: HT/GMP Pilot	Basket diameter	Basket length	Filtering surface	Cake volume	Slurry density	Max load	Max speed	G factor	Centrifuge weight
Unit	mm	mm	m²	dm³	kg/dm³	kg	RPM	xg	kg
300/110	300	110	0,1	7	1,25	9	3150	1663	1400
470/180	470	180	0,27	27	1,25	34	2300	1390	3000

- On request, the system can be implemented to isolate the process area from the service area with a flexible membrane. Machines of a new generation with an inverted filter can significantly reduce the volume of a clean room and allow the process zone to be enclosed in a protective chamber.

- It is easy to reconfigure the machine for use in multi-purpose plants, as there is no cross-contamination because of CIP washing system.

- Operating modes: fully automatic through PLC or DCS, semiautomatic, manual.

- Limited headroom required.

- Filter cloth fastened to the basket by two flanges for an easy and quick replacement.

- New design allows filter cloth replacement without opening the protective chamber, thus meeting the most stringent requirements for controlling the spread of contaminants.

HT/GMP inverting filter centrifuge

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HT/GMP inverting filter centrifuge

MediBalt Ltd - representative of Comi Condor

Model description